Pyrrolizidine Alkaloide in Petasites fragrans

Pyrrolizidine alkaloids in human diet.

Pyrrolizidine alkaloids are the leading plant toxins associated with disease in humans and animals. Upon ingestion, metabolic activation in liver converts the parent compounds into highly reactive electrophiles capable of reacting with cellular macromolecules forming adducts which may initiate acute or chronic toxicity. The pyrrolizidine alkaloids present a serious health risk to human populati...

Pyrrolizidine Alkaloids from Heliotropium

Investigation of the pyrrolizidine alkaloids of Heliotropium arbainense resulted in the isolation and identification of heliotrine, europine and 7-angelylheliotrine. From H. ovalifolium three alkaloids were isolated: supinine, 7-angelylheliotridine and an alkaloid which was shown to be of the heliotridine monoester type with a dehydrated viridifloric acid.

Pyrrolizidine alkaloids in honey and bee pollen.

A total of 3917 honey samples and 119 'bee pollen' samples (pollen collected by honeybees) were analysed for pyrrolizidine alkaloids (PAs). Some 0.05 M sulphuric acid was used for extraction followed by a clean-up step by means of solid-phase extraction. Separation and detection was achieved by target analysis using an LC-MS/MS system. PAs were found in 66% of the raw honeys (bulk honey not yet...

Lipid Lowering Effects of Myristica Fragrans

Pyrrolizidine Alkaloids from Heliotropium indicum

Um novo alcalóide denominado Helindicina (1), e o conhecido licopsamina (2) foram isolados das raízes de Heliotropium indicum (Boraginaceae). As estruturas foram estabelecidas tendo como base um amplo estudo de 1D e 2D RMN (COSY, HMBC, HMQC, NOESY) e HREIMS. Este representa o primeiro relato de um alcalóide contendo um anel lacônico no gênero Heliotropium. Estes alcalóides mostraram moderada at...